WP4 defines and validates patient eligibility criteria to identify new cohorts who stand to benefit from the modular CAR-T device, leveraging clinical expertise and data analytics to model anticipated outcomes. A comprehensive market and competitor analysis maps current trends, barriers to entry, and growth projections, informing optimal positioning within healthcare systems. Finally, insights from WP2 are used for exploitation and sustainability strategies that outline clear commercialization pathways, partner engagement, and scalable roll-out plans to ensure long-term integration and impact of the innovation.
Same-day CAR-T production is established and refined through the comparison of novel vector and gene-editing strategies with classical methods. Both processes are then standardized to ensure consistent, clinical-scale use. It develops cutting-edge analytical assays - leveraging CRISPR off-target profiling, 3D ex vivo efficacy screens, and cytokine-release monitoring - to qualify edited cells for safety and potency. Finally, it conducts paired comparisons of the new rapid workflow versus traditional ex vivo culture to demonstrate equivalence or superiority in product quality.
George is a molecular pharmacologist who completed his PhD in collaboration with Pfizer. He leads a research group and a university spin-out company dedicated to developing novel therapies for diseases driven by aberrant cyclic AMP signaling systems. His team addresses a wide spectrum of conditions, including prostate cancer, Huntington's disease, cardiovascular disorders, and rare diseases such as Acrodysostosis type II. Their translational research is supported by pharmaceutical companies and national government funding schemes.
Nattaporn is a research scientist specialising in CAR-T cell immunotherapy for solid tumours. She holds a PhD in Immunology (International Program) from Mahidol University, Thailand, where her thesis focused on “Chimeric antigen-receptor engineered T cells targeting integrin αvβ6 for cholangiocarcinoma”. She currently serves as Research Associate at University of Glasgow in the UK, contributing to translational research in advanced cell-based therapies.